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Sreekumar, S.
- Cadmium-Zinc-Telluride Imager On-Board Astrosat:A Multi-Faceted Hard X-Ray Instrument
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Authors
Affiliations
1 Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, IN
2 Inter-University Centre for Astronomy and Astrophysics, Pune 411 007, IN
3 Physical Research Laboratory, Ahmedabad 380 009, IN
4 Vikram Sarabhai Space Centre, Thiruvananthapuram 695 024, IN
1 Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, IN
2 Inter-University Centre for Astronomy and Astrophysics, Pune 411 007, IN
3 Physical Research Laboratory, Ahmedabad 380 009, IN
4 Vikram Sarabhai Space Centre, Thiruvananthapuram 695 024, IN
Source
Current Science, Vol 113, No 04 (2017), Pagination: 595-598Abstract
The AstroSat satellite is designed to make multi-waveband observations of astronomical sources and the Cadmium-Zinc-Telluride Imager (CZTI) instrument of AstroSat covers the hard X-ray band. CZTI has a large area position-sensitive hard X-ray detector equipped with a coded aperture mask, thus enabling simultaneous background measurements. Ability to record simultaneous detection of ionizing interactions in multiple detector elements is a special feature of the instrument, and this is exploited to provide polarization information in the 100-380 keV region. CZTI provides sensitive spectroscopic measurements in the 20-100 keV region, and acts as an all-sky hard X-ray monitor and polarimeter above 100 keV. During the first year of operation, CZTI has recorded several gamma-ray bursts, measured the phase-resolved hard X-ray polarization of the Crab pulsar, and the hard X-ray spectra of many bright galactic X-ray binaries. The excellent timing capability of the instrument has been demonstrated with simultaneous observation of the Crab pulsar with radio telescopes like Gaint Metrewave Radio Telescope and Ooty Radio Telescope.Keywords
All-Sky Hard X-Ray Monitor, Gamma-Ray Bursts, Neutron Stars, X-Ray Polarization.References
- Singh, K. P. et al., AstroSat mission. In Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series: Space Telescopes and Instrumentation 2014: UV to Gamma Ray, at Montreal, 2014, vol. 9144, 91441S (p. 15).
- Bhalerao, V. et al., The Cadmium–Zinc–Telluride Imager on AstroSat. JAA, 2017, 38, 31.
- Bhalerao, V., Bhattacharya, D., Rao, A. R. and Vadawale, S., GRB151006A: AstroSat CZTI detection. GRB Coordinates Network, 2015, 18422, 1.
- Rao, A. R. et al., AstroSat CZT Imager observations of GRB151006A: timing, spectroscopy, and polarization study. ApJ, 2016, 833, 86.
- Bhalerao, V. et al., LIGO/Virgo G211117: AstroSat CZTI upper limits. GRB Coordinates Network, 2016, 19401, 1.
- Bhalerao, V., Bhattacharya, D., Rao, A. R. and Vadawale, S., GRB170105A: AstroSat CZTI localisation. GRB Coordinates Network, 2016, 20412, 1.
- Chattopadhyay, T., Vadawale, S. V., Rao, A. R., Sreekumar, S., and Bhattacharya, D., Prospects of hard X-ray polarimetry with AstroSat–CZTI. Exp. Astron., 2014, 37, 555.
- Vadawale, S. V. et al., Hard X-ray polarimetry with AstroSat–CZTI. Astron. Astrophys., 2015, 578, A73.
- Buhler, R. and Blandford, R., The surprising Crab pulsar and its nebula: a review. Rep. Prog. Phys., 2014, 77(6), 066901.
- Lyne, A. G., Pritchard, R. S. and Graham-Smith, F., Twenty-three years of Crab pulsar rotational history. MNRAS, 1993, 265, 1003.
- In vitro and In silico Validation of Anti-Cobra Venom Activity and Identification of Lead Molecules in Aegle marmelos (L.) Correa
Abstract Views :321 |
PDF Views:82
Authors
Affiliations
1 Saraswathy Thangavelu Centre, Biotechnology and Bioinformatics Division, Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Puthenthope, Thiruvananthapuram 695 586, IN
2 Department of Zoology, University College, Thiruvananthapuram 695 034, IN
1 Saraswathy Thangavelu Centre, Biotechnology and Bioinformatics Division, Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Puthenthope, Thiruvananthapuram 695 586, IN
2 Department of Zoology, University College, Thiruvananthapuram 695 034, IN
Source
Current Science, Vol 114, No 06 (2018), Pagination: 1214-1221Abstract
Venomous snakebite is a global serious health issue and in India high rate of mortality is caused by Naja naja (Indian cobra). To evaluate anti-cobra venom activity and identify lead molecules in Aegle marmelos, in vitro and in silico screening was carried out. Leaves, stem and ischolar_main bark of A. marmelos were extracted in ethanol, methanol and hexane and maximum yield was obtained in methanol. All extracts were used for testing in vitro anti-haemolytic, inhibition of anti-acetylcholinesterase and anti-proteolytic activities. The results revealed that ethanol extract of ischolar_main bark has high anti-haemolytic activity, methanol extracts of leaves have the highest inhibitory effect on venom induced anti-acetylcholinesterase activity and ethanol extracts of leaves have maximum anti-proteolytic activity. Docking between 81 phytochemicals from A. marmelos and each of the 14 cobra venom toxic proteins revealed that the plant contains potential molecules for detoxification of all the cobra venom proteins.Keywords
Aegle marmelos, Cobra Venom, Docking, Phytochemicals, Snakebite.References
- Mohapatra, B., Warrell, D. A., Suraweera, W., Bhatia, P. and Dhingra, N., Snakebite mortality in India: A nationally representative mortality survey. PLoS. Negl. Trop. Dis., 2011, 5, e1018.
- Kasturiratne, A. et al., The global burden of snakebite: A literature analysis and modelling based on regional estimates of envenoming and deaths. PLoS Med., 2008, 5, e218.
- Lalla, J. K., Sunita, O., Priyanka, G., Zaid, T. and Geeta T., Snakebite problem in India: An overview. Sch. Acad. J. Pharm., 2013, 2, 252–259.
- Nisha, N. C., Sreekumar, S., Biju, C. K. and Krishnan, P. N., Snake antivenom: Virtual screening of plant derived molecules. Biobytes, 2010, 6, 14–22.
- Vyas, V. K., Brahmbhatt, K., Bhatt, H. and Parmar, U., Therapeutic potential of snake venom in cancer therapy: current perspectives. Asian Pac. J. Trop. Biomed., 2013, 3, 156–162.
- Binh, D. V., Thanh, T. T. and Chi, P. V., Proteomic characterization of the thermostable toxins from Naja naja venom. J. Venom. Anim. Toxins Incl. Trop. Dis., 2010, 16, 631–638.
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- Raju, M. S., Native plants used in snakebite and other poisonous animals among the tribals of East Godavari district, Andhra Pradesh. Aryavaidyan, 1996, 9, 251–255.
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- Vijayabharathi, R. A., Kumar, S. and Kumar, K. S., In vitro and in vivo anti-snake venom activity of Coccinia indica L. leaf. Hamdard Med., 2005, 48, 132–135.
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- Nisha, N. C., Sreekumar, S., Biju, C. K. and Krishnan, P. N., Identification of lead compounds with cobra venom neutralizing activity in three Indian medicinal plants. Int. J. Pharm. Pharm. Sci., 2014, 6, 536–541.
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- Morris, G. M., Huey, R., Lindstrom, W., Sanner, M. F., Belew, R. K., Goodsell, D. S. and Olson, A. J., AutoDock4 and AutoDock-Tools4: Automated docking with selective receptor flexibility. J. Comput. Chem., 2009, 30, 2785–2791.
- Nisha, N. C., Sreekumar, S. and Biju, C. K., Identification of lead compounds with cobra venom detoxification activity in Andrographis paniculata (Burm. F.) Nees through in silico method. Int. J. Pharm. Pharm. Sci., 2016, 8, 212–217.
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- Mitul, P., Handral, M. and Swaroop, T. V. S. S., Anti-venom activity of Cinnamomum zeylanicum extracts against Naja kauthia snake venom. Int. J. Pharm. Chem. Biol. Sci., 2013, 2, 1302–1310.
- Maiorano, V. A. et al., Antiophidian properties of the aqueous extract of Mikania glomerata. J. Ethnopharmacol., 2005, 102, 364–370.
- Alam, M. I. and Gomes, A., Snake venom neutralization by Indian medicinal plants (Vitex negundo and Emblica officinalis) ischolar_main extracts. J. Ethnopharmacol., 2003, 86, 75–80.
- Monimala, M. and Mukherjee, A. K., Neutralisation of lethality, myotoxicity and toxic enzymes of Naja kaouthia venom by Mimosa pudica ischolar_main extracts. J. Ethnopharmacol., 2001, 75, 55–60.
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- Janardhan, B., Shrikanth, V. M., Mirajkar, K. K. and More, S. S., In vitro screening and evaluation of antivenom phytochemicals from Azima tetracantha Lam. leaves against Bungarus caeruleus and Vipera russelli. J. Venom. Anim. Toxins Incl. Trop. Dis., 2014, 1, 1.
- Wireless Instrumentation System Experiment
Abstract Views :167 |
PDF Views:87
Authors
Bibin Varghese
1,
S. Sreelal
1,
S. Sreekumar
1,
P. Vinod
1,
M. N. Namboothiripad
1,
Joseph Lal
2,
K. Anand
2
Affiliations
1 Avionics Entity, and Vikram Sarabhai Space Centre, Indian Space Research Organisation, Thiruvananthapuram 695 022, IN
2 Advanced Space Transportation Systems, Vikram Sarabhai Space Centre, Indian Space Research Organisation, Thiruvananthapuram 695 022, IN
1 Avionics Entity, and Vikram Sarabhai Space Centre, Indian Space Research Organisation, Thiruvananthapuram 695 022, IN
2 Advanced Space Transportation Systems, Vikram Sarabhai Space Centre, Indian Space Research Organisation, Thiruvananthapuram 695 022, IN
Source
Current Science, Vol 120, No 1 (2021), Pagination: 152-160Abstract
This article describes the design details of a Wireless Instrumentation System that was experimented in ISRO’s recent Human in Space Project (HSP) Pad Abort Test (PAT) mission in piggy-back mode. The system consists of a few Wireless Sensor Nodes (WSNs) that acquire parameter data and a Wireless Base Station that collects these over an IEEE 802.15.4 compatible single-hop RF link and forward it to the telemetry subsystem. The circuit configuration, communication link and protocol as well as the measurement plan as adopted for HSP-PAT flight test are described to bring out the scalability of the architecture. The performance of the system in HSP-PAT mission is discussed in detail by way of PFA analysis results. All the parameters monitored through the system, including inertial ones such as acceleration and rotation were compared with reference data obtained from functional Telemetry Telecommand and Power and Navigation Guidance and Control chains and showed normal signatures. Maintaining an uninterrupted wireless communication channel in a hostile and crowded chamber like the Crew Module for all the nodes has called for a robust Medium Access Control (MAC) layer based on the industry-popular IEEE802.15.4 RF PHY. The requirement of such a robust MAC layer is established when the radio frequency links outage encountered in one of the WSN links during the interval of high vehicle dynamics is seen to be taken care of by the diverse link of the same node. A future roadmap towards self-powered wireless sensors is also outlined.Keywords
Data Acquisition, Human In Space Project, Launch Vehicle Telemetry, Wireless Sensor Network.References
- Pillai, S. S. et al., A versatile, software programmable telemetry system for satellite launch vehicles. In Proceedings of International Telemetering Conference (ITC 06), San Diego, USA, October 2006.
- Jose, S. et al., Instrumentation and baseband telemetry for RLV-TD Hex mission. J. Inst. Eng. (India): Ser. C, 2017, 98(6), 697–704.
- Varghese, B., Sreelal, S., Sreekumar, S., Vinod, P. and Mookiah, T., IEEE802.15.4 based efficient beaconing MAC for real-time aerospace applications. In IEEE International Conference on Signal Processing, Informatics, Communication and Energy Systems (IEEE SPICES 2015), NIT Calicut, February 2015.
- Varghese, B., John, N. E., Sreelal, S. and Gopal, K., Design and development of an RF Energy Harvesting Wireless Sensor Node (EH-WSN) for aerospace applications. In Sixth International Conference on Advances in Computing and Communications (ICACC 2016), Cochin, September 2016; Reprinted in Procedia Comput. Sci., 2016, 93, 230–237.
- Kesuma, H., Sebald, J., Ahobala, T. and Paul, S., Ariane 5 Space Launcher Vehicle Equipment Bay Wireless Sensor Network Telemetry Subsystem with Smart Sensors, In 36th European Telemetry and Test Conference, Nuremberg, Germany, 2016, pp.233–238.
- Tati, D., Klaue, J. and Sebald, J., Reliable real-time wireless sensor networks using spatial diversity. In IEEE International Conference on Wireless for Space and Extreme Environments (WiSEE), Aachen, Germany, 2016.
- Blanckenstein, J., Nardin, C., Klaue, J. and Karl, H., Error characterization of multi-access point WSN’s in an aircraft cabin. In ICC 2015 Workshop on Dependable Vehicular Communications, June 2015.
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